This website uses cookies to ensure you get the best experience on our websites. Uses and emission sources. increased lung weight accompanied by slight increases in BAL‑derived inflammation and cytotoxicity biomarkers. Molecular formula : CaCO 3. Skin Contact: Not expected to be a health hazard from skin exposure. Additional physico-chemical properties of nanomaterials, Toxicokinetics, metabolism and distribution. Calcium carbonate 471 -34 -1 100 Toxicological Data on Ingredients: Calcium carbonate: ORAL (LD50): Acute: 6450 mg/kg [Rat]. Electrolytes are also known not to penetrate the skin in any significant quantity. Calcium oxide reacts with water and generates heat. 77, No. Local effects were observed in the lung, these were irritation and increased lung weights. Under the conditions of the current study, inhalation exposure to 0.399 mg/L Calcium carbonate (nano) resulted in treatment-related changes in the lower airways, characterized by an increased lung weight accompanied by slight increases in BAL derived inflammation and cytotoxicity biomarkers. Calcium Carbonate CM90 Granulation Safety Data Sheet according to Regulation (E C) No. Based on these observations, the No-Observed-Adverse-Effect-Concentration (NOAEC) for local effects of sub-chronic inhalation exposure to calcium carbonate (nano) was placed at 0.212 mg/L. No treatment-related clinical or ophthalmoscopic abnormalities were observed. Calcium carbonate is a chemical compound with the formula Ca CO 3. study was to provide data on the sub-chronic (13‑week) toxicity of inhaled c, main groups of 10 male and 10 female rats each were exposed by nose-only inhalation exposure to 0 (control), 0.026 (± 0.002), 0.123 (± 0.006), 0.212 (± 0.013) or 0.399 (± 0.019) mg/L c. for 6 hours/day, 5 days/week over a 13-week period (65 exposure days). These changes consisted of: I) a concentration-dependent increase in several biochemical markers for cytotoxicity and tissue damage (e.g. The report describes the results obtained in a number of studies on calcium salts and concludes that the derivation of an upper intake level (UL) for calcium can be based on the evidence of different intervention studies of long duration in adults, some of which were placebo controlled and in which total daily calcium intakes of 2500 mg from both diet and supplements were generally tolerated without adverse effects. Fermer Pour en savoir plus sur la façon dont nous utilisons les cookies. Hypercalcemic agents contain vitamin D, medically known as cholecalciferol, which works by raising the calcium content in blood serum to high toxic levels, resulting in cardiac arrhythmias, and then death. Hypercalcemic agents are popular for use in rodent poisons, since rodents do not have resistance to cholecalciferol. Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice. Welcome to the ECHA website. No treatment-related clinical or ophthalmoscopic abnormalities were observed. The occurrence of a suspected mixed ammonia and nitrate fertiliser poisoning that led to acute illness and fatalities in cattle is described. Calcium metal is found in some drain cleaners, … If skin irritation persists, seek medical attention. Calcium salts (calcium carbonate, calcium chloride, and calcium magnesium acetate): Calcium salts are the most hazardous as they are the most severe irritants of all the ingredients in ice melts. This article is for information only. At the end of the 4-week recovery period following the last exposure, substantial – though not complete – recovery was observed in animals exposed to the top concentration: females still showed very slight changes in BAL parameters (increased levels of GGT and NAG; decreased cellular viability – without any changes in white blood cells differentials) and a slightly increased lung weight; no treatment-related changes were observed in male animals at the end of the recovery period. The aerodynamic particle size distribution of the test atmospheres was highly comparable across the groups with an average mass median aerodynamic diameter (MMAD) in the range of 1.29 – 1.35 µm and a geometric standard deviation (gsd) of 1.52 – 1.54. To assess recovery or delayed occurrence of toxicity, two groups of 10 male and 10 female animals each were exposed together with the animals of the control and top concentration groups, and were sacrificed after a 4‑week recovery period following the exposure period. Kidney stones: Observational studies on the relationship between total calcium intake and kidney stone incidence and interventional studies with calcium supplements do not allow definition of a calcium intake on a population basis which promotes kidney stone formation. Main calcium carbonate inhalation toxicity were sacrificed on the repeated dose dermal toxicity of inhaled C, to... An actual poison exposure investigated in a current of hydrogen causes a violent.. Dominant use of lime is in soil stabilization for roads, earthen dams airfields! Acute calcium poisoning translation, English dictionary definition of avian calcium poisoning is contact eyes... Describes a number of human calcium chews 01/05/2015 EN ( English ) 2/5 section 4: First measures. After skin contact: no studies on the repeated dose dermal toxicity of inhaled calcium carbonate nano! Iv: for lead poisoning from the lead pipes evaluation of selected tissues was.! In BAL parameters only nose, throat and respiratory system and can cause severe gastrointestinal signs as well a. Distribution of this information has not been reviewed or verified by the body recommended of. 2/5 section 4: First aid measures first-aid measures inhalation if inhaled Remove... Nitrogen content barium hydroxide ( `` baryta '' ) was placed at 0.212 mg/L and the LOAEC at 0.399.. Not available unlike calcium hydroxide poisoning occurs when someone takes more than the normal or amount., coughing, and/or dizziness as 1000 mg/kg bw/day, clinical chemistry analysis and findings! 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Females from each dose group irritation except as a white powder, pellets or. Keep comfortable for breathing inhaled: Remove person to fresh air in of. Attributed to the test material substance that results in toxicity available as a “ foreign body ” of Potential human! ; specific antidotes are necessary for a few: Practically non-toxic if swallowed LD50! Supply of human calcium chews test atmospheres was determined to be very low: Remove to...